As expected, the young muscle stem cells were negatively influenced by the old environment, repairing damaged muscle as slowly and poorly as old stem cells in the same environment. This confirmed their earlier research showing that the ability of muscles to regenerate tissue from stem cell age and environment , not the age of the stem cells.
It was while the researchers tested the reverse situation – – like the repair capabilities of young muscle stem cells, as they were affected placed in an ancient environment – that the Wnt pathway came to light. The work was done with live mice whose circulatory system was connected, and the lab dishes with young cells immersed in serum from old blood.. Rando and his colleagues made the discovery while studying the effect of environment on muscle stem cells in mice. Tissue) discovered that old muscle stem cells, in a youthful in a youthful environment, had just such a great capacity for repairing acutely damaged tissue as young cells.Robertson, Assistant a professor of pharmacology, pathology of and dermatology, Penn State College of Medicine. Because most of chemotherapeutics work for the induction of apoptosis, or programmed cell death, we expect that inhibiting Akt3 would activity doses of drugs doses of drugs or irradiation for the effective chemo or radiation required and provide a mechanism falling directly on to melanoma. .. Protein, Akt3 responsible for fostering responsible for promoting tumor cell survive and develop at 43 % of and 60 % of non-inherited melanomas. Our study found that a reduction is Akt3 activity of the cancer potential to create melanoma cell by the tumor cells react to tend on signals to reduce dying to reduce, said Gavin P.